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目的:探讨干燥综合征(SS)病理分析对诊断SS的意义及SS、Mikulicz病与粘膜相关淋巴组织(MALT)型淋巴瘤的关系.方法:回顾性分析159例经病理证实的SS,对疑为MALT型淋巴瘤的6例用免疫组化ABC法标记,使用抗体LCA、bcl.2、UCHL－1、L26及免疫球蛋白IgG、IgA、IgM、IgD、lgE和κ、λ.结果:6例可疑病例中有4例发生MALT型淋巴瘤,免疫组化LCA、L26、bcl－2、IgM、κ和IgM、λ呈阳性.结论:①下唇粘膜、泪腺、腮腺活检进行病理分级对于诊断SS有重要意义;②MALT型淋巴瘤的发生与SS、Miklulicz病有一定的关系.“,”Purpose To study the diagnostic implication of Sjogren\'s syndrome\'s pathological grde and thecorrelation among Sjogren\'s syndrome, Mikulicz\'s disease and MALT-ML. Methods ImrnunohistochemistryABC method was used in 6 of 159 cases SS, which were suspected MALT-ML and antibody LCA, UCHL-1,L26, bcl-2, IgA, IgG, IgM, IgD, IgE, κ and λ were included. Results 4 of 6 suspect cases were MALT-MLin which LCA, L26, bcl-2, IgM/κ and IgM/λ were positive expression. Conclusion (1 ) Pathological grade oflower lip, lacrimal gland and salivary gland has important significance in diagnosis SS. (2) MALT-ML is relatedto SS and Mikulicz\'s disease.