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前列腺癌是泌尿系统肿瘤最常见的肿瘤之一,其发病率和死亡率有增长趋势。因此,寻找一种特异的诊断指标以早期发现前列腺癌显得尤为重要。近年发现在前列腺癌中由于DNA过度甲基化造成失活的基因很多,其中谷胱甘肽S转移酶P1目前研究较多,最有希望成为一个新的前列腺癌标志物。本文就近年来有关GSTP1过甲基化与前列腺癌的关系作一综述。
Prostate cancer is one of the most common tumors of urinary system tumors, and its morbidity and mortality are increasing. Therefore, looking for a specific diagnostic indicator to detect prostate cancer is particularly important. In recent years, found in prostate cancer due to DNA over-methylation caused by many genes, including glutathione S-transferase P1 currently more research, most promising to become a new marker of prostate cancer. This article reviews the relationship between GSTP1 hypermethylation and prostate cancer in recent years.