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采用新生大鼠胰岛离体培养方法，观察了五肽胃泌素（Ｇ－５）对ＩＬ－１Ｂ致胰岛Ｂ细胞分泌抑制的影响。结果表明：（１）ＩＬ－１Ｂ能剂量依赖性抑制Ｂ细胞的分泌功能；（２）Ｇ－５能对抗ＩＬ－１Ｂ对Ｂ细胞功能的抑制，与单纯ＩＬ－１Ｂ作用组相比，加用Ｇ－５能使葡萄糖刺激的胰岛素分泌量明显增加：（３）向ＩＬ－１Ｂ作用后的胰岛治疗性地给予Ｇ－５．能使抑制的Ｂ细胞功能得到部分恢复，作用呈时间和剂量依赖性。
The effects of pentagastrin (G-5) on IL-1B-induced pancreatic islet B cell secretion were observed in cultured rat islets isolated from neonatal rats. The results showed that: (1) IL-1B could inhibit the secretion of B cells in a dose-dependent manner; (2) G-5 could antagonize the inhibitory effect of IL-1B on B cells. Compared with IL- G-5 markedly increases glucose-stimulated insulin secretion: (3) G-5 is therapeutically administered to islets following IL-1B administration. Can inhibit the function of B cells to be partially restored, the role of time and dose-dependent.