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目的 探讨血管内皮细胞生长因子 (VEGF)和 nm2 3与血管生成及胃癌发展的关系。方法 采用免疫组织化学 S- P法对 40例人胃癌组织中的 VEGF、nm2 3蛋白表达和微血管密度 (MVD)进行检测 ,分析其与胃癌组织学类型、浸润深度、淋巴结转移和预后的关系。结果 VEGF阳性者 (MVD)值显著高于阴性者 (P<0 .0 1) ,VEGF表达率和 MVD值与胃癌浸润深度、淋巴结转移呈正相关 (P<0 .0 5 ) ,nm2 3高表达者 MVD值显著低于 nm2 3低表达者 (P<0 .0 5 ) ,nm2 3高表达与淋巴结转移呈负相关 (P<0 .0 1)。结论 VEGF可促进肿瘤血管生成 ,nm2 3可能有阻碍血管生成的作用。 MVD、VEGF和 nm2 3均可作为反映胃癌生物学行为的指标之一。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and nm23 in angiogenesis and gastric cancer. Methods The expressions of VEGF, nm23 protein and microvessel density (MVD) in 40 human gastric cancer tissues were detected by immunohistochemical S-P method. The relationship between the expression of VEGF, nm23 protein and the histological type, depth of invasion, lymph node metastasis and prognosis were analyzed. Results The VEGF positive rate (MVD) was significantly higher than that of negative ones (P <0.01). The expression of VEGF and MVD were positively correlated with the depth of invasion and lymph node metastasis (P <0.05) MVD was significantly lower than those with low expression of nm23 (P <0. 05). The high expression of nm23 was negatively correlated with lymph node metastasis (P <0.01). Conclusion VEGF can promote tumor angiogenesis, nm23 may impede angiogenesis. MVD, VEGF and nm2 3 can be used as one of the indicators reflecting the biological behavior of gastric cancer.