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目的:探究脑脊液置换联合鞘内注射用于诊治结核性脑膜炎的效果。方法:选取2010年2月至2012年12月收治的患有结核性脑膜炎病人共64例,随机分作对照组和试验组,每组32例,常规药物用来治疗这两组,而试验组额外附加脑脊液置换联合鞘内注射治疗。结果:比较两组患者总有效率,在差异上有统计学意义(P<0.05);治疗前后两组病人的蛋白、糖、氯化物、白细胞、压力指标比较,差异均具有统计学意义(P<0.05);诊治后试验组病人的蛋白、糖、氯化物、白细胞、压力指标明显比对照组好(P<0.05)。结论:脑脊液置换方法联合鞘内注射使得患者脑脊液加快恢复,体征及临床症状得到好转,并发症的发生减少,有效率地提高治疗,因而是治疗结核性脑膜炎有效、安全的方法。
Objective: To explore the effect of cerebrospinal fluid replacement combined with intrathecal injection in the diagnosis and treatment of tuberculous meningitis. Methods: A total of 64 patients with tuberculous meningitis who were admitted from February 2010 to December 2012 were randomly divided into control group and experimental group, with 32 patients in each group. Conventional drugs were used to treat both groups. However, Additional cerebrospinal fluid replacement combined with intrathecal injection. Results: The total effective rate of the two groups was statistically significant (P <0.05). The differences of protein, glucose, chloride, leukocyte and pressure before and after treatment between the two groups were statistically significant (P <0.05). After diagnosis and treatment, the protein, sugar, chloride, leukocyte and pressure index in the test group were significantly better than those in the control group (P <0.05). Conclusion: Cerebrospinal fluid replacement combined with intrathecal injection can accelerate the recovery of cerebrospinal fluid (CSF), improve the signs and clinical symptoms, reduce the incidence of complications and improve the treatment efficiently. Therefore, it is an effective and safe method for the treatment of tuberculous meningitis.