肠道病毒71型(EV71)感染引起手足口病并可导致神经源性疾病,而免疫受损或不成熟与EV71感染的发病率和致死率升高密切相关。Ⅰ型干扰素(IFN)是抗病毒感染的第1道防线。但小鼠模型中EV71不能促进Ⅰ型干扰素产生,且加入针对IFN-α/β的中和抗体可使病毒感染症状恶化。该过程中的分 Infectious enterovirus 71 (EV71) causes hand-foot-mouth disease and can lead to neurogenic diseases, while impaired or immature immunity is closely associated with an increased incidence of EV71 infection and an increased lethality. Type I interferon (IFN) is the first line of defense against viral infections. However, EV71 did not promote type I IFN production in the mouse model, and the addition of neutralizing antibodies to IFN-α / β could worsen the symptoms of viral infection. The points in the process