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目的探讨孕前期和孕早期疾病与先天性心脏病的关系。方法采用以医院为基础病例对照研究方法,对123名病例和246名对照进行问卷调查。采用多因素非条件Logistic逐步回归模型分析孕前期和孕早期疾病对先天性心脏病的影响。结果孕前期患慢性疾病、孕早期感冒、孕前期和孕早期生殖系统感染、异常生育史等增加先天性心脏病发生的风险,其OR值分别为3.084(95%CI:0.826~11.513),2.023(95%CI:1.220~2.353),1.750(95%CI:1.026~2.986),3.617(95%CI:1.488~8.792)。结论母亲孕前期和孕早期疾病与先天性心脏病的发生有关,应重视与加强孕前期和孕早期疾病的防治,以预防先天性心脏病的发生。
Objective To investigate the relationship between congenital heart disease and pre-pregnancy and early pregnancy diseases. Methods A hospital-based case-control study was conducted to investigate 123 cases and 246 controls. Multivariate non-conditional Logistic stepwise regression model was used to analyze the effect of pre-pregnancy and early-pregnancy disease on congenital heart disease. Results The risk of congenital heart disease was 3.084 (95% CI: 0.826-11.513) and 2.023 (2.023) respectively, with the risk of congenital heart disease in the first trimester, such as chronic diseases, flu in the first trimester, reproductive system infection in the first trimester and the first trimester, abnormal pregnancy history, (95% CI: 1.220-2.353), 1.750 (95% CI: 1.026-2.986), 3.617 (95% CI: 1.488-8.792). Conclusion Maternal pregnancy and early pregnancy disease and congenital heart disease, emphasis should be placed on strengthening and prevention of pre-pregnancy and early pregnancy disease in order to prevent the occurrence of congenital heart disease.