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用标准的生物学方法检测了肾小球和系膜细胞培养上清中转化生长因子(TGF_s)的水平。结果显示:肾小球和系膜细胞均可产生一定量的TGF_s;肾小球产生的THF_s无活性,而系膜细胞产生的TGF_s大约10％有活性。鉴于TGF_s在调节细胞生长和细胞外基质代谢中的独特作用,肾小球和系膜细胞来源的rGF_s可能在维持正常肾小球结构和功能中起重要作用。
The levels of transforming growth factor (TGF-β) in glomerular and mesangial cell culture supernatants were measured using standard biological methods. The results showed that glomerulus and mesangial cells can produce a certain amount of TGF_s; glomerular THF_s produced no activity, and mesangial cells generated TGF_s about 10% activity. Glomerular and mesangial cell-derived rGF_s may play an important role in maintaining normal glomerular structure and function, in view of the unique role of TGF-β in regulating cell growth and extracellular matrix metabolism.