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目前,HIV-1致AIDS 病的作用已被肯定。这种反转录病毒只作用于CD_4~+的细胞。CD_4分子在病毒进入细胞的过程中起着病毒受体的作用。虽然CD_4~+的T 淋巴细胞是病毒的主要靶细胞,但是其它表达CD_4分子的细胞如单核-吞噬细胞,朗罕氏细胞和神经胶质细胞等也是易感细胞。无论是发病病人还是无明显症状的HIV 阳性患者均有不同程度的免疫缺陷。但是,细胞免疫异常与免疫病理之间的关系仍还不清。本文就最近细胞免疫缺陷的研究进展作如下综述。
At present, the role of HIV-1-induced AIDS has been affirmed. This retrovirus only acts on CD_4 ~ + cells. The CD 4 molecule acts as a viral receptor in the process of entry of the virus into the cell. Although CD4 + T lymphocytes are the major target cells of the virus, other CD4-expressing cells such as monocytes-phagocytes, Langerhans cells and glial cells are also susceptible cells. Both HIV-positive patients with or without obvious symptoms have varying degrees of immunodeficiency. However, the relationship between cellular immune abnormalities and immunopathology remains unclear. This article summarizes recent advances in cellular immune deficiency.