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目的:研究蔓荆子生物碱体外抗氧化的活性。方法:运用Fenton体系和邻苯三酚自氧化法评价蔓荆子生物碱体外抗氧化的能力,采用多元线性回归分析生物碱浓度与抗氧化活性的相关性。结果:蔓荆子生物碱对—OH和O2-清除能力与其浓度呈明显的量效关系;其生物碱浓度与对—OH清除能力呈正相关,与对O2-清除能力呈负相关。结论:蔓荆子生物碱具有较强的抗氧化能力,是1种天然有效的抗氧化剂。
Objective: To study the anti-oxidative activity of Vitex negundo alkaloids in vitro. Methods: The anti-oxidative ability of alkaloids from Vitex negundo was evaluated by Fenton system and pyrogallol autoxidation. The correlation between alkaloid concentration and anti-oxidative activity was analyzed by multivariate linear regression analysis. Results: The alkaloids of Vitex negundo showed obvious dose-effect relationship with -OH and O2-scavenging ability. The alkaloid concentration was positively correlated with the scavenging ability of -OH and negatively with the scavenging capacity of O2-. Conclusion: Vitex alkaloids have a strong antioxidant capacity, is a natural and effective antioxidant.