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我院对119例住院的中老年患者临床上有打鼾、白天嗜睡、乏力和夜间有睡眠呼吸暂停的病人进行了多导仪监测夜间睡眠呼吸。其中60例确诊为睡眠呼吸暂停综合征。简称SAS,59例排除了SAS,并对患有SAS与非SAS两组病人进行对比,发现有SAS组患有冠心病者22例,非SAS组患有冠心病的有12例,两组比较SAS组比非SAS组冠心病发病率高,而且有显著差异(P<0.05)。在SAS组有冠心病的病人中有8例夜间发生心肌缺氧,ECG表现ST—T改变。同时还发现SAS患者中 几乎都有不同程度的SaO_2降低,在8例夜间发生心肌缺血时,其中有6例发生在SaO_2<90％,2例发生在SaO_2>90％。考虑SAS可引起低氧血症,血液动力学改变,冠状动脉氧含量降低,从而引起或加速冠状动脉硬化形成及心肌缺血的发生。所以,SAS可能是冠心病的一个危险因素。
119 cases of hospitalized middle-aged and elderly patients in our hospital were clinically snoring, daytime drowsiness, fatigue and sleep apnea patients at night with multi-channel instrument to monitor sleep at night. 60 cases were diagnosed as sleep apnea syndrome. Referred to as SAS, 59 patients ruled out SAS, and with SAS and non-SAS patients were compared and found SAS patients with coronary heart disease in 22 cases, non-SAS group had coronary heart disease in 12 cases, two groups compared The incidence of coronary heart disease in SAS group was higher than that in non-SAS group, and there was significant difference (P <0.05). In the SAS group of patients with coronary heart disease, 8 patients developed myocardial oxygen deficiency at night, and ECG showed ST-T changes. At the same time, there were almost all SAS patients with varying degrees of reduction of SaO_2. In 8 patients with myocardial ischemia at night, 6 cases occurred in SaO_2 <90% and 2 cases in SaO_2> 90%. Considering SAS can cause hypoxemia, hemodynamic changes, decreased coronary oxygen content, causing or accelerating the formation of coronary atherosclerosis and myocardial ischemia. Therefore, SAS may be a risk factor for coronary heart disease.