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成年小鼠经口给予醋酸铅500、100O、2000(mg·kg)/d连续28天。光镜观察发现:睾丸生精小管萎缩,生精细胞脱落、变性,层次减少、核固缩,随醋酸铅剂量增加,睾丸生精上皮病变加重;附睾管内出现大量精子细胞和精母细胞。电镜观察发现;1000mg/kg组小鼠睾丸精子细胞核变形,核染色质异常聚集;附睾精子轴丝变性浓缩,残余胞质增多,残余胞质内出现多个溶酶体,精子头核染色质成团块状,核液化,顶体破坏。
Adult mice were orally administered lead acetate 500,100O, 2000 (mg · kg) / d for 28 consecutive days. Light microscope observation showed that testicular seminiferous tubules atrophy, spermatogenic cells shedding, degeneration, level reduction, nuclear pyknosis, with the lead acetate dose increased testicular germ epithelial lesions aggravated; epididymal tube appeared a large number of sperm cells and spermatocytes. Electron microscopy showed that nuclei in testis of 1000 mg / kg mice were abnormally deformed and nuclear chromatin was abnormally aggregated. Axal degeneration and condensation of epididymal sperm spindle and increased residual cytoplasm resulted in multiple lysosomes in the residual cytoplasm. Lumpy, nuclear liquefaction, acrosome destruction.