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目的研究晚期血吸虫病(晚血)合并HBV感染对肝纤维化的影响。方法对94例晚血患者的肝脏活检组织进行HBsAg免疫组化检测,根据HBsAg是否阳性对病例进行分组。采用Masson三色、苦味酸天狼猩红特殊染色法,对患者慢性肝炎炎症活动和肝纤维化程度进行分级和分期。结果94例晚血患者中,合并HBV感染者40例(42.55%),43例患者(45.74%)肝组织中查出血吸虫卵。患者合并HBV感染后,慢性肝炎炎症活动程度及肝纤维化程度均较单纯晚血患者严重(P均<0.01);肝组织虫卵阳性与阴性患者肝纤维化程度差异均无统计学意义(P均>0.05)。结论晚血合并HBV感染患者肝脏炎症活动程度和肝纤维化程度均明显加重。
Objective To study the effect of late schistosomiasis (late blood) combined with HBV infection on hepatic fibrosis. Methods The liver biopsies of 94 patients with late blood were detected by HBsAg immunohistochemistry, and the cases were divided into groups according to whether HBsAg was positive or not. Masson trichrome and picric acid Sirius Red staining were used to grade and stage chronic hepatitis with inflammatory activity and liver fibrosis. Results Of 94 patients with late blood, 40 (42.55%) patients with HBV infection and 43 (45.74%) patients with schistosomiasis were found in liver tissue. Patients with HBV infection, the severity of chronic hepatitis and degree of liver fibrosis were worse than those of patients with purely late blood (P <0.01); liver tissue between positive and negative patients with egg-induced liver fibrosis no significant difference (P All> 0.05). Conclusions The degree of hepatic inflammation and hepatic fibrosis in patients with late blood and HBV infection are significantly aggravated.