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口服避孕药中的孕酮制剂不仅能影响子宫内膜的敏感性和干扰排卵周期,而且还将显著的改变宫颈粘液的物化性状和抑制精子的移动。因此,有人介绍于宫颈局部给予低剂量的孕酮制剂可能是一个有效的避孕方法。正常的月经周期中,宫颈粘液性状的变化显著的受血液中黄体酮浓度的影响。从停经至排卵体内黄体酮浓度为0.5ng/ml,宫颈粘液粘度低,经体外测定精子的穿透速率为42±7.mm/min。排卵后体内黄体酮浓度上升到5—10ng/ml,且维持几天。这时宫颈粘液少而粘,测得的精子穿透速率约是7±4.8mm/hr。如果宫颈内能维持较高的黄体酮水平,则宫颈粘液能阻止受孕。这样的黄
Progesterone preparations in oral contraceptives not only affect endometrial sensitivity and interfere with ovulation cycles, but also significantly alter the physico-chemical properties of cervical mucus and inhibit sperm motility. Therefore, it was suggested that topical administration of low doses of progesterone to the cervix may be an effective contraceptive method. In the normal menstrual cycle, changes in cervical mucus properties are significantly affected by progesterone concentrations in the blood. From menopause to ovulation in vivo progesterone concentration of 0.5ng / ml, cervical mucus viscosity is low, in vitro determination of sperm penetration rate of 42 ± 7.mm / min. After ovulation in vivo progesterone concentration rose to 5-10ng / ml, and maintain a few days. At this time cervical mucus less sticky, the measured rate of penetration of sperm is about 7 ± 4.8mm / hr. If the cervix can maintain a high progesterone level, cervical mucus can prevent pregnancy. This yellow