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近年来国内许多学者认为免疫复合物参与流行性出血热(EHF)发病机理,并对此开展了大量的研究工作。各家相继报导EHF 各病期病人血清中检出循环免疫复合物(CIC),尸检肾脏有免疫复合物(IC)沉积。CIC 水平急性期高于恢复期,其动力学变化与病期转归密切相关,但于恢复期病人血清中,CIC 仍维持一定的高度。更应注意的是Jokine氏发现有些EHF 病人于发病后8个月仍能检出CIC;国内刘志勋发现1例EHF,CIC 持续78天。我们为进一步探讨EHF 各病期均有较高水平的CIC,但其致病作用不同的问题,曾于1981和1982年检测各病期CIC 的沉降系数及CIC 水平动态与吞噬功能的关系。试验结果证明各病期CIC 沉降系数无明显差异,而与吞噬功能密切相关。现将后者检测方法及结果介绍如下。
In recent years, many domestic scholars believe that immune complexes are involved in the pathogenesis of epidemic hemorrhagic fever (EHF), and have carried out a large number of research work. Various reports of circulating immune complexes (CICs) were detected in the sera of patients with EHF at different stages, and deposition of immune complexes (ICs) in autopsy kidneys. The level of CIC in acute phase is higher than that in convalescent phase, and the change of kinetics is closely related to the prognosis. However, the level of CIC in convalescent serum remains the same. More should be noted that Jokine found that some EHF patients 8 months after the onset of CIC can still be detected; the domestic Liu Zhixun found 1 case of EHF, CIC lasted 78 days. In order to further explore the high level of CIC in each stage of EHF, the pathogenesis of CIC was different. In 1981 and 1982, the relationship between sedimentation coefficient and the level of CIC and phagocytosis was examined. The test results show that there is no significant difference in CIC sedimentation coefficient between stages, but closely related to phagocytosis. Now the latter test methods and results are described below.