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目的 :探讨表皮生长因子受体 (EGFR)和转化生长因子 -α(TGFα)在前列腺癌 (PCa)中表达的临床意义。方法 :采用免疫组化法检测 43例 PCa组织和 5例正常前列腺组织中 EGFR和 TGFα的表达。结果 :正常前列腺组织中 EGFR和 TGFα分别表达在上皮细胞和基质中。 EGFR和 TGFα在 PCa细胞上的共同表达率为5 5 .8% ,二者密切相关 (r =0 .5 19) ,并与 PCa分期有关 (P <0 .0 1) ;此类患者的生存时间明显短于 EGFR和TGFα阴性表达的患者 (P <0 .0 1)。结论 :EGFR和 TGFα形成的自分泌环可能与 PCa恶化和内分泌治疗失败有关 ,同时检测它们可作为判断 PCa临床分期、预后的一个重要指标。
Objective: To investigate the clinical significance of the expression of epidermal growth factor receptor (EGFR) and transforming growth factor-α (TGFα) in prostate cancer (PCa). Methods: Immunohistochemistry was used to detect the expression of EGFR and TGFα in 43 cases of PCa and 5 cases of normal prostate tissue. Results: EGFR and TGFα were expressed in epithelial cells and stroma respectively in normal prostate tissue. The common expression rate of EGFR and TGFα in PCa cells was 55.8%, which was closely related to that of PCa (r = 0.519) (P <0.01). The survival rate of these patients Time was significantly shorter than EGFR and TGFα negative expression of patients (P <0.01). CONCLUSION: The autocrine loop formed by EGFR and TGFα may be related to the deterioration of PCa and the failure of endocrine therapy. At the same time, they can be used as an important index to judge the clinical stage and prognosis of PCa.