论文部分内容阅读
目的探讨CD4+CD25+调节性T细胞(Treg细胞)在晚期肺癌中的表达及其临床意义。方法应用流式细胞术分析30例晚期肺癌患者外周血CD4+CD25+Treg细胞表达水平,与10例健康人比较。结果晚期肺癌患者外周血CD4+CD25+Treg细胞数量增加(17.9±6.1)%,表达高于正常人(6.81±0.4)%(P<0.001)。肺癌患者外周血中Treg细胞数量与患者的病理类型无关(P>0.05),但与临床分期和组织学分化程度有关(P<0.01)。结论Treg细胞在肺癌患者中比率明显升高,并与临床进展有关。
Objective To investigate the expression of CD4 + CD25 + regulatory T cells (Tregs) in advanced lung cancer and its clinical significance. Methods The expression of CD4 + CD25 + Treg cells in peripheral blood of 30 patients with advanced lung cancer was analyzed by flow cytometry, compared with 10 healthy people. Results The number of CD4 + CD25 + Treg cells in peripheral blood increased (17.9 ± 6.1)% in patients with advanced lung cancer and was significantly higher than that in normal people (6.81 ± 0.4)% (P <0.001). The number of Treg cells in peripheral blood of patients with lung cancer was not related to the pathological type (P> 0.05), but correlated with clinical stage and histological differentiation (P <0.01). Conclusion The percentage of Treg cells in patients with lung cancer is significantly higher than that in patients with advanced lung cancer.