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目的研究频率为3 GHz的平面微波照射下培养板中细胞样品的剂量分布。方法和模型采用时域有限差分法(FDTD)计算六孔板中2 ml/孔细胞样品的比吸收率(SAR)。微波源为线极化波,极化和入射分别沿垂直、水平方向共8种照射条件。结果给出了不同照射条件下细胞悬液和细胞单层平均SAR及孔间、孔内SAR均匀性和分布图,以及模型简化引入平均SAR的计算误差。结论离体细胞样品对微波的吸收效率和剂量均匀性随入射和极化方向的不同而不同,生物学效应实验设计必须建立在准确的剂量学评估基础之上。
Objective To study the dose distribution of the cell samples in the plate under the irradiation of plane microwave with the frequency of 3 GHz. Methods and Models Specific absorption rate (SAR) of 2 ml / well of 6-well plates in a six-well plate was calculated using the FDTD method. Microwave source for the linear polarization, polarization and incident along the vertical, horizontal, a total of eight kinds of irradiation conditions. Results The average SAR and the uniformity and distribution of SAR in the cell suspension and cell monolayer under different irradiation conditions and the calculation error of the average SAR introduced by the model simplification are given. Conclusion The absorption efficiency and dose uniformity of microwave in vitro are different with different directions of incidence and polarization. The design of biological effects experiment must be based on accurate dosimetry evaluation.