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目的探讨福辛普利、螺内酯及美托洛尔治疗左心室射血分数降低慢性心力衰竭的临床疗效。方法选取2014年10月—2015年10月于兴业县人民医院收治的124例左心室射血分数降低慢性心力衰竭患者,按照随机数字表法分为对照组与试验组,各62例。两组患者均给予对症治疗,对照组在此基础上给予螺内酯、美托洛尔治疗,试验组在对照组基础上加用福辛普利钠片治疗。比较两组患者临床疗效、6min步行试验、B型脑钠肽、左心室射血分数、左心室舒张末期内径、左心室收缩末期内径,并观察两组患者不良反应发生情况。结果试验组患者总有效率高于对照组(P<0.05)。试验组患者6min步行试验长于对照组,B型脑钠肽水平低于对照组,左心室射血分数高于对照组,左心室舒张末期内径、左心室收缩末期内径小于对照组,不良反应发生率低于对照组(P<0.05)。结论福辛普利、螺内酯及美托洛尔联合治疗左心室射血分数降低慢性心力衰竭的临床疗效确切,可改善患者心功能指标,且不良反应少。
Objective To investigate the clinical efficacy of fosinopril, spironolactone and metoprolol in the treatment of left ventricular ejection fraction to reduce chronic heart failure. Methods A total of 124 patients with chronic heart failure with left ventricular ejection fraction were enrolled in Xingye County People’s Hospital from October 2014 to October 2015. The patients were divided into control group and trial group according to random number table method, 62 cases in each. Two groups of patients were given symptomatic treatment, the control group on the basis of spironolactone, metoprolol treatment, the experimental group in the control group based on the use of fosinopril sodium tablets. The clinical efficacy, 6-minute walk test, B-type natriuretic peptide, left ventricular ejection fraction, end-diastolic diameter of left ventricle and end-systolic diameter of left ventricle were compared between the two groups. The occurrence of adverse reactions in both groups were also observed. Results The total effective rate of the experimental group was higher than that of the control group (P <0.05). The 6-minute walk test in trial group was longer than that in control group, the level of B-type brain natriuretic peptide was lower than that in control group, the left ventricular ejection fraction was higher than that in control group, the diameter of left ventricular end-diastole and the diameter of left ventricular end-systole were smaller than those in control group Lower than the control group (P <0.05). Conclusion The combination of fosinopril, spironolactone and metoprolol in the treatment of left ventricular ejection fraction decreased the clinical curative effect of chronic heart failure, can improve the patient’s cardiac function, and less adverse reactions.