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用放射免疫方法测定了２０例正常儿童及４０例急性白血病（ＡＬ）患儿化疗前后血清肿瘤坏死因子α（ＴＮＦ－α）活性。结果：在ＡＬ诊断时，ＴＮＦ－α活性显著升高；当患儿获得部分缓解到完全缓解时，ＴＮＦ－α活性进步降低，其最低值仍高于健康儿童（Ｐ＜０．０１～０．０５）；急性淋巴细胞白血病（ＡＬＬ）患儿血清ＴＮＦ－α在任何阶段都低于急性非淋巴细胞白血病（ＡＮＬＬ）患儿（Ｐ＜０．０１）；血清ＴＮＦ－α水平和临床疗效之间显示负相关性。作者认为测量血清ＴＮＦ－α活性可以作为一项判断ＡＬ疗效和预后的临床指标。
Serum levels of tumor necrosis factor alpha (TNF-alpha) were measured in 20 normal children and 40 children with acute leukemia (AL) before and after chemotherapy by radioimmunoassay. Results: The activity of TNF-α was significantly increased at diagnosis of AL. The TNF-α activity decreased progressively when the children were partly relieved and completely relieved. The lowest level was still higher than that of healthy children (P <0.01-0). (P <0.01). The serum levels of TNF-α and clinical efficacy were lower in children with acute lymphoblastic leukemia (ALL) than in children with acute non-lymphocytic leukemia (ANLL) at any stage Show negative correlation. The authors believe that the measurement of serum TNF-α activity can be used as a clinical indicator of AL efficacy and prognosis.