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目的观察胃腺癌石蜡包埋标本中MAC30蛋白的表达变化,并分析其临床意义。方法采用免疫组化SP法检测20例正常胃黏膜组织及40例胃腺癌组织中MAC30蛋白的表达。结果胃腺癌组织MAC30表达阳性率为65%(26/40),明显高于正常胃黏膜组织中的15%(3/20),差异有统计学意义(P<0.05);在胃腺癌中,MAC30蛋白与淋巴结转移有关(P<0.05)。结论胃腺癌组织中MAC30蛋白高表达可能与胃腺癌的发生和转移有关。
Objective To observe the expression of MAC30 protein in paraffin embedded specimens of gastric adenocarcinoma and to analyze its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of MAC30 protein in 20 cases of normal gastric mucosa and 40 cases of gastric adenocarcinoma. Results The positive rate of MAC30 in gastric adenocarcinoma was 65% (26/40), which was significantly higher than that in normal gastric mucosa (15%, 3/20) (P <0.05). In gastric adenocarcinoma, MAC30 protein was associated with lymph node metastasis (P <0.05). Conclusion The high expression of MAC30 in gastric adenocarcinoma may be related to the occurrence and metastasis of gastric adenocarcinoma.