论文部分内容阅读
目的通过回顾性研究,了解艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)乙型肝炎(简称乙肝)病毒(HBV)、丙型肝炎(简称丙肝)病毒(IHCV)、梅毒的感染率及乙肝病毒表面抗体(HBsAb)的阳性率,为预防HIV/AIDS病人发生合并感染提供理论依据。方法 2014年8月1日至2015年7月31日,对在北京地坛医院皮肤科门诊开始抗病毒治疗的1 010例成年HIV/AIDS病人,收集基线的人口学资料和临床资料,使用描述性统计学方法分析HIV/AIDS病人HBV、HCV和梅毒的感染率。结果 1 010例HIV/AIDS病人的年龄中位数为29(26~37)岁,96.14%(971例)为男性,91.39%(923例)的病人通过性途径感染HIV。931例病人在基线检测了乙肝病毒表面抗原(HBsAg),阳性率为6.55%(61例)。918例病人在基线检测了HBsAb,阳性率为58.71%(539例),28.98%(266例)病人HBsAb的数值>100 mIU/mI。921例病人检测了抗-HCV,阳性率为2.28%(21例)。870例病人进行了甲苯胺红不加热血清试验(TRUST),阳性率为24.48%(213例)。男性HIV/AIDS病人合并梅毒的感染率比女性高(P=0.043),70.42%(150/213)的HI+V/梅毒病人TRUST的滴度≥1:4。结论HIV/AIDS病人合并I-IBV感染率相对较高,HBsAb阳性率低,在适当的时机应进行乙肝疫苗的接种或补种。虽然HIV/AIDS病人合并HCV感染率相对比较低,但这部分人群依旧是存在的,必要的时候应建议启动丙肝的治疗。HIV/AIDS病人合并梅毒感染率很高,临床医生在工作中应向病人宣传如何有效地预防性传播疾病,即使高效抗病毒治疗后,HIV核糖核酸处于检测下限,HIV/AIDS病人也应使用安全套。
Objective To investigate the relationship between Hepatitis B virus (HBV) and hepatitis C virus (HCV) in Hepatitis A virus (HIV) , The syphilis infection rate and the positive rate of hepatitis B virus surface antibody (HBsAb) provide a theoretical basis for preventing the co-infection of HIV / AIDS patients. Methods From August 1, 2014 to July 31, 2015, baseline and demographic data and clinical data of 1,010 adult HIV / AIDS patients who started antiretroviral therapy at Dermatology Clinic of Beijing Ditan Hospital were collected. Descriptiveness The statistical method was used to analyze the infection rates of HBV, HCV and syphilis in HIV / AIDS patients. Results The median age of 1 010 HIV / AIDS patients was 29 (26-37) years old, 96.14% (971) were male, and 91.39% (923) were HIV infected through sexual route. 931 patients were tested for hepatitis B virus surface antigen (HBsAg) at baseline, the positive rate was 6.55% (61 cases). HBsAb was detected in 918 patients at 58.71% (539 patients) at baseline, and HBsAb values> 100 mIU / mI in 28.98% (266 patients). 921 patients tested anti-HCV, the positive rate was 2.28% (21 cases). 870 patients underwent toluidine red unheated serum test (TRUST), the positive rate was 24.48% (213 cases). The prevalence of syphilis was higher in men with HIV / AIDS than in women (P = 0.043). TRUST titers ≥1: 4 in 70.42% (150/213) of HI + V / syphilis patients. Conclusion The HIV / AIDS patients have a relatively high infection rate of I-IBV and a low positive rate of HBsAb. Hepatitis B vaccine should be vaccinated or replanted at the appropriate time. Although HIV / AIDS patients with relatively low rates of HCV infection, but this part of the population is still there, it is recommended when necessary to start the treatment of hepatitis C. HIV / AIDS patients have a high prevalence of syphilis, and clinicians should advise patients on how to effectively prevent sexually transmitted diseases during their work. Even HIV / AIDS patients should use condoms even after highly effective antiviral therapy .