论文部分内容阅读
全球疾病负担中的85%以上发生于发展中国家,而其中13%是妇科恶性肿瘤[1]。妇科恶性肿瘤日趋明显的高发生率以及患者的年轻化使其成为威胁全球女性的一大杀手。对于妇科肿瘤方面的基因治疗一直是近些年的研究热点。Fascin,又名成束蛋白,通过与F-肌动蛋白结合,参与细胞骨架的构成,促使细胞膜结构发生改变,从而降低细胞间的稳定性,增加细胞的运动能力。研究发现,Fascin在人类多种肿瘤组织中表达上调,与肿瘤的发生发展、侵袭转移以及患者的预后密切相
More than 85% of the global burden of disease occurs in developing countries, of which 13% are gynecological malignancies [1]. The growing and apparent high incidence of gynecological malignancies and the rejuvenation of their patients make them a major killer to women worldwide. Gene therapy for gynecologic oncology has been a hot topic in recent years. Fascin, also known as fascin, binds to F-actin and participates in the formation of the cytoskeleton, resulting in changes in the cell membrane structure, thereby reducing cell-cell stability and increasing cell motility. The study found that Fascin is up-regulated in a variety of human tumor tissues, which is closely related to tumorigenesis, invasion and metastasis and the prognosis of the patients