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研究证明鸟类出生后前庭系统有缓慢产生毛细胞的能力.鸟类和哺乳类前庭毛细胞受损后可以再生,推测支持细胞、神经上皮细胞是再生毛细胞的可能前体细胞.初步证明TGF-α可能是一种细胞有丝分裂因子.一些基因产物、生长因子及转录因子(如视黄酸和甲状腺素)可能参与调节内耳毛细胞的产生过程.为人类前庭上皮毛细胞再生提供了重要依据.为前庭平衡障碍者展现可能获治的前景.本文重点综述了前庭毛细胞再生的机制.
Studies have shown that the vestibular system after birth in birds have the ability to slowly produce hair cells.Before the birds and mammalian vestibular hair cells can be damaged after regeneration, speculated that supporting cells, neural epithelial cells is a possible precursor of regenerative hair cells.Preliminary evidence of TGF -α may be a mitogenic factor.Many gene products, growth factors and transcription factors (such as retinoic acid and thyroxine) may be involved in the regulation of inner ear hair cell production, which provides an important basis for the regeneration of human vestibular epithelial cells. Showing potential for treatment of vestibular balance disorders in this article focuses on the mechanism of vestibular hair cell regeneration.