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【目的】研究早产儿脑白质损伤与母亲孕期合并先兆子痫的关系。【方法】通过影像学检查,观察了72例先兆子痫母亲所生早产儿脑白质损伤的演变。分析脑白质损伤的程度与先兆子痫程度的关系,分析重度脑白质损伤与重度先兆子痫的类型和并发症的关系。【结果】本组早产儿脑白质损伤的情况:轻度损伤(一过性脑室旁强回声)27例,重度损伤45例(脑室旁白质软化5例;脑室扩大40例)。重度先兆子痫组早产儿重度脑白质损伤的发生率(71.1%)明显高于轻度先兆子痫组(44.4%)(P<0.05)。早发型重度先兆子痫组早产儿重度脑白质损伤的发生率(76.5%)明显高于晚发型重度先兆子痫组(60.0%)(P<0.01);重度先兆子痫有并发症组早产儿重度脑白质损伤的发生率(84.4%)明显高于无并发症组(41.7%)(P<0.01)。【结论】母亲重度先兆子痫,尤其是早发型和有并发症的重度先兆子痫,对早产儿重度脑白质损伤的发生有重要影响。
【Objective】 To investigate the relationship between white matter damage in premature infants and pre-eclampsia with maternal pregnancy. 【Methods】 The changes of white matter damage in preterm infants born from 72 pregnant women with preeclampsia were observed by imaging examination. To analyze the relationship between the degree of white matter damage and the degree of preeclampsia, and to analyze the relationship between the type of severe preeclampsia and the complications of severe white matter damage. 【Results】 The incidence of white matter damage in preterm infants of this group was 27 cases of mild injury (transient echogenic) and 45 cases of severe injury (5 cases of ventricular white matter softening and 40 cases of ventricular enlargement). The incidence of severe white matter damage in premature children with severe preeclampsia (71.1%) was significantly higher than that in mild preeclampsia (44.4%) (P <0.05). The incidence of severe white matter damage in premature infants with early-onset severe preeclampsia (76.5%) was significantly higher than that in late-onset severe preeclampsia (60.0%) (P <0.01). Premature infants with severe preeclampsia had complications The incidence of severe white matter damage (84.4%) was significantly higher than that of the non-complication group (41.7%) (P <0.01). 【Conclusion】 Maternal severe preeclampsia, especially early-onset and severe pre-eclampsia with complications, has an important effect on the occurrence of severe white matter damage in premature infants.