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[目的] 探讨血清人附睾蛋白(HE4)、糖类抗原125(CA125)、CA199联合检测诊断妇科恶性肿瘤的价值.[方法] 检测42例妇科恶性肿瘤患者(A组)及同期收治的42例妇科良性肿瘤者(B组)HE4、CA125、CA199水平,比较不同标志物及联合检测的阳性率和相关指标.[结果] A组HE4、CA125、CA199表达水平、三项标志物单项检测及联合检测阳性率均高于B组,且差异有显著性(P<0.05);A组不同标志物联合检测阳性率、ROC曲线下面积(AUC)、准确性、特异性、灵敏度均高于CA125、CA199单独检测(P<0.05),其阳性率、AUC、准确性、特异性与HE4单独检测时无明显差异(P<0.05),但灵敏度显著高于HE4单独检测(P<0.05).[结论] HE4诊断妇科恶性肿瘤的价值优于CA125、CA199,三者联合诊断可进一步提高良恶性肿瘤鉴别诊断率.“,”[Objective]To explore the application value of the combined detection of serum human epididymis protein (HE4), carbohydrate antigen 125 (CA125) and CA199 in the diagnosis of gynecologic malignant tumors.[Methods]Forty-two patients with gynecologic malignant tumors (group A) and 42 patients with gynecologic benign tumors (group B) were selected as study subjects.All cases underwent detection of HE4, CA125 and CA199.The positive rates of the three markers and ROC were compared.[Results]The expression levels of HE4, CA125 and CA199 individually and in combination in group A were significantly higher than those in group B (P<0.05).The positive rate, AUC under ROC curve, accuracy, specificity and sensitivity for the detection of the combination of markers in group A were higher than those of CA125 and CA199 alone (P0.05).However, the sensitivity of the combined detection was significantly higher than that of HE4 alone (P<0.05).[Conclusion]The value of HE4 in diagnosing gynecologic malignant tumors is higher than CA125 and CA199 alone.The combined diagnosis of the three markers can further improve the differential diagnosis rate.