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目的研究7～17岁儿童生长激素分泌水平,并探讨血清铁、血清锌和血铅含量对生长激素分泌的影响。方法采取分层整群抽样对济宁市744名7～17岁青少年儿童,空腹采集静脉血5ml,运用放射免疫法测定血清生长激素含量,分光光度法测定血清铁含量,电位溶出法测定血清锌和全血中铅的含量。结果男、女童生长激素分泌的突增年龄分别为11岁和9岁;9～10岁年龄段女童分泌量显著高于男童,12岁以后男童分泌水平反超女童;随着血清铁含量的增加,生长激素分泌量呈逐渐增大趋势,低、中、高3个血清铁含量组生长激素分泌量差异有统计学意义(F=18.78,P<0.05);锌充足组生长激素分泌量高于缺乏组,差异有统计学意义(t=9.338,P<0.01);随着血铅含量增加,生长激素分泌水平逐渐降低,经方差分析显示:相对安全组、超标组和高铅组生长激素分泌量差异有统计学意义(F=6.68,P<0.05)。结论女童生长激素分泌的突增期早于男童;血清中铁、锌含量的增加能促进生长激素的分泌,血铅的增加则抑制生长激素的分泌。
Objective To study the growth hormone secretion in children aged 7 to 17 and to explore the effect of serum iron, serum zinc and blood lead on the growth hormone secretion. Methods Stratified cluster sampling was performed on 744 children aged 7-17 years old in Jining City. Blood samples were collected for 5 ml fasting serum, radioimmunoassay for determination of serum growth hormone, spectrophotometric determination of serum iron content, The content of lead in whole blood. Results The growth of somatotropin in boys and girls were 11 and 9 years old, respectively. The girls in 9 ~ 10 years old had significantly higher secretion than girls, (F = 18.78, P <0.05). The secretion of growth hormone in zinc adequate group was significantly higher than that in normal control group In the lack of group, the difference was statistically significant (t = 9.338, P <0.01); with the increase of blood lead, the level of growth hormone secretion gradually decreased. Analysis of variance showed that: relative safety group, excessive group and high lead group growth hormone There was significant difference in the amount of secretion (F = 6.68, P <0.05). Conclusions The sudden increase of GH secretion in girls is earlier than that in boys. The increase of iron and zinc in serum can promote the secretion of growth hormone. The increase of serum lead can inhibit the secretion of growth hormone.