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目的 :研究肝舒胶囊在 2 .2 .15细胞培养中抗乙型肝炎病毒 (HBV)作用。方法 :用 2 .2 .15细胞体外培养 ,对肝舒胶囊抗 HBV活性进行评价。结果 :肝舒胶囊 5 g/ L加药后 4d对 2 .2 .15细胞 HBs Ag和 HBe Ag的抑制率为 5 1.16 %和 74.83% ,在加药后第 8天抑制作用达高峰 ,对 HBs Ag和 HBe Ag的抑制率分别为 75 .72 %和80 .0 2 %。药物作用 12 d时 ,其治疗指数可达 7.73和 5 .39。结论 :肝舒胶囊在体外细胞培养中对 HBs Ag和 HBe Ag的分泌均有较好的抑制作用。
Objective : To study the anti-hepatitis B virus (HBV) effect of Heshu Capsule in cell culture of 2.2.15. Methods : The anti-HBV activity of Ganshu capsule was evaluated by in vitro culture with 2.2.15 cells. Results: The inhibitory rate of HBsAg and HBe Ag in 2.2.15 cells was 5.11% and 74.83% at the 4th day after Gansu Capsule was administered 5 g/L, and the inhibition peaked at 8 days after dosing. The inhibition rates of Ag and HBe Ag were 75.72% and 80.0%, respectively. After 12 days of drug action, the therapeutic index was 7.73 and 5.39. Conclusion : Ganshu Capsules have good inhibitory effect on the secretion of HBsAg and HBeAg in vitro.