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氯化钾片或肠溶氯化钾片,引起胃肠溃疡的频率很高。作者用膜包衣技术制成恒速控制释药的KCl 片剂,从而使副作用减至最低程度。用50%PVP 乙醇-丙酮(1:1)溶液制KCl 颗粒,湿粒在鼓风烘箱中于40°干燥2小时,压成12mm 圆形凸片(每片含KCl 1000mg)为片心。将聚氯乙烯(PVC,单体含量<1ppm)配成13%丙酮溶液,混悬粒度<10μm 的蔗糖微化粉作为包衣液。KCl 片置包衣锅内,用0.1mm 喷嘴,以30ml/min 喷速喷雾包衣液直
Potassium chloride tablets or enteric-coated potassium chloride tablets, gastrointestinal ulcers caused by a high frequency. The authors used a film-coating technique to make constant-release controlled-release tablets of KCl, minimizing side effects. KCl pellets were prepared using a 50% solution of PVP in ethanol-acetone (1: 1) and the wet pellets were dried in a forced air oven at 40 ° for 2 hours and pressed into round pellets (each containing KCl 1000 mg) as a pellet. Polyvinyl chloride (PVC, monomer content <1ppm) dubbed 13% acetone solution, suspended particle size <10μm of sucrose micronized powder as a coating solution. KCl piece set coating pan, with 0.1mm nozzle, spray coating solution at a speed of 30ml / min straight