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目的研究天麻钩藤降压复方提取物的镇静作用。方法灌胃给药,连续给药5 d,末次给药1 h后,分别腹腔注射戊巴比妥钠55 mg/kg和硫代氨基脲16 mg/kg(0.1 mL/10 g),记录睡眠时间、睡眠恢复时间和惊厥时间(惊厥潜伏期),惊厥次数。结果天麻钩藤降压复方提取物大剂量(31.2 g生药/kg)连续给药5次能延长戊巴比妥钠引起小鼠睡眠时间、延长硫代氨基脲所致小鼠惊厥潜伏期、减少小鼠自主活动次数,与模型组比较差异具有统计学意义(P<0.05)。结论天麻钩藤降压复方提取物有一定的镇静作用。
Objective To study the sedative effect of extract of Tianma Uncaria decompression Compound. Methods The rats were administrated intragastrically for 5 days and the rats were anesthetized with sodium pentobarbital 55 mg / kg and thiosemicarbazide 16 mg / kg (0.1 mL / 10 g) ip Time, sleep recovery time and convulsion time (convulsion latency), the number of seizures. Results Tianma Gouteng antihypertensive compound extract large doses (31.2 g crude drug / kg) 5 consecutive doses of sodium pentobarbital can prolong the sleep-induced mice to extend the latency of mice seizures caused by thiosemicarbazide to reduce the small The number of spontaneous activity of rats, compared with the model group, the difference was statistically significant (P <0.05). Conclusion Tianma Uncaria antihypertensive compound extract has some sedation.