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目的研究医师-药师协作模式对静脉血栓栓塞症(VTE)患者治疗的影响。方法 90例急性VTE患者依据入院时间先后顺序分为对照组与观察组,各45例。两组患者均采用华法林治疗,对照组采用常规治疗管理方法 ,观察组在对照组基础上采用医师-药师协作模式对患者进行治疗管理,观察比较两组患者治疗效果。结果观察组住院时间及VTE复发、发生出血事件、出院后按时复诊、出院后国际标准化比值(INR)达标率分别为(8.1±5.1)d、0、0、91.1%、84.4%,对照组住院时间及VTE复发、发生出血事件、出院后按时复诊、出院后INR达标率分别为(10.8±5.9)d、11.1%、8.9%、71.1%、48.9%,两组比较差异具有统计学意义(P<0.05)。治疗结束3个月后对全部患者进行影像学复查发现,观察组阴性率为88.9%(40/45),对照组阴性率为46.7%(21/45),差异具有统计学意义(P<0.05)。结论对VTE患者的管理采用医师-药师协作管理模式,能够有效提高治疗效果,改善服用华法林的患者INR达标情况,减少复发,降低出血的风险。
Objective To investigate the effect of physician-pharmacist collaboration on the treatment of patients with venous thromboembolism (VTE). Methods 90 cases of acute VTE patients were divided into control group and observation group according to the sequence of admission time, 45 cases in each. Two groups of patients were treated with warfarin, the control group using conventional treatment management methods, the observation group in the control group based on the physician-pharmacist collaborative mode of treatment and management of patients, the treatment was observed and compared two groups of patients. Results The hospitalization time, recurrence of VTE and bleeding in the observation group were followed up on time. The compliance rate of international standardization ratio (INR) after discharge was (8.1 ± 5.1) d, 0,0,91.1% and 84.4% respectively. The control group (10.8 ± 5.9) d, 11.1%, 8.9%, 71.1% and 48.9% respectively after discharge from hospital, the difference between the two groups was statistically significant (P <0.05). Three months after the end of treatment, radiographic examination of all patients showed that the negative rate was 88.9% (40/45) in the observation group and 46.7% (21/45) in the control group, with statistical significance (P <0.05 ). Conclusions The management of VTE patients with physician-pharmacist collaborative management mode can effectively improve the therapeutic effect, improve the compliance of patients with warfarin in INR, reduce the recurrence and reduce the risk of bleeding.