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目的探讨Galectin-3和Smad4在结肠癌及相应的癌旁组织中的表达差异及其与结肠癌生物学行为的关系。方法应用免疫组化S-P法检测Galectin-3和Smad4在61例结肠癌组织及对应癌旁组织中的表达情况。结果61例结肠癌中Galectin-3阳性表达50例,阳性率为82%,对应癌旁组织中Galectin-3表达阳性率为26.2%,差异有统计学意义(P<0.05)。结肠癌中Smad4阳性率为24.6%,对应癌旁组织中阳性率为80.3%,差异有统计学意义(P<0.05)。Galectin-3的阳性表达及Smad4表达缺失与大肠癌分化程度、浸润和转移有关(P<0.01或<0.05)。结论Galectin-3在结肠癌组织中表达率高,与结肠癌细胞的淋巴结转移、浸润有关,Smad4表达缺失与大肠癌分化程度和转移有关。二者是预测结肠癌转移的较有价值的指标。
Objective To investigate the expression difference of Galectin-3 and Smad4 in colon cancer and corresponding paracancerous tissues and their relationship with the biological behavior of colon cancer. Methods The expression of Galectin-3 and Smad4 was detected by immunohistochemistry S-P method in 61 cases of colorectal cancer tissues and corresponding paracancerous tissues. Results The positive expression rate of Galectin-3 in 61 cases of colon cancer was 50%, the positive rate was 82%. The positive rate of Galectin-3 in corresponding paracancerous tissues was 26.2%, with statistical significance (P <0.05). The positive rate of Smad4 in colon cancer was 24.6%, corresponding to 80.3% in paracancerous tissues, the difference was statistically significant (P <0.05). The positive expression of Galectin-3 and the loss of Smad4 expression were related to the differentiation, invasion and metastasis of colorectal carcinoma (P <0.01 or <0.05). Conclusions Galectin-3 is highly expressed in colon cancer tissues, which is related to lymph node metastasis and infiltration of colon cancer cells. The loss of Smad4 expression is related to the differentiation and metastasis of colorectal cancer. Both are more valuable predictors of colon cancer metastasis.