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地高辛是一种广泛用于治疗充血性心力衰竭与心房纤颤的药物.但不同的地高辛片剂生物利用度的差异相当大(50～90%),因而给该药的临床应用带来了困难.本研究的目的旨在测定两种地高辛片剂(产品A:地高辛-Pharbita 0.25mg/片,产品B:地高辛0.25mg/片)单次给药后的相对生物利用度.研究对象为10名健康青年志愿者,男女各半,年龄22.3±0.8岁,体重67.4±12.0kg.受试者受试前和受试期间2周内未服用过任何其它药物.两种剂型都为空腹服用,于服药后0.25,0.50,0.75,1,
Digoxin is a widely used drug for the treatment of congestive heart failure and atrial fibrillation, but varies widely among bioavailability tablets (50-90%), thus giving the drug its clinical utility Brought about difficulties.The purpose of this study was to determine the effect of two digoxin tablets (product A: digoxin-Pharbita 0.25 mg / tablet, product B: digoxin 0.25 mg / tablet) Relative bioavailability.The study was conducted on 10 healthy young volunteers, male and female, aged 22.3 ± 0.8 years old and weighing 67.4 ± 12.0 kg.The subjects had not taken any other medication before and during the 2 weeks Both dosage forms are taken on an empty stomach, after taking 0.25,0.50,0.75,1,