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目的:探讨胰岛素样生长因子-1(IGF-1)、转化生长因子-β1(TGF-β1)水平变化在过敏性紫癜患儿肾损害发病机制中作用。方法:选取HSP患儿30例、HSPN患儿30例和30例健康儿童为对照组,分别采血,用化学发光法检测各组标本IGF-1浓度,采用双抗体一步夹心法酶联免疫吸附试验检测各组TGF-β1浓度;同时用全自动生化仪检测各组患儿血清Cys C、BUN、SCr水平。结果:血IGF-1、TGF-β1的水平HSPN组、HSP组与对照组患儿比较,差异均有统计学意义(P<0.05)。血清Cys C水平对照组、HSP组与HSPN组患儿比较,差异有统计学意义(P<0.05)。采用直线相关分析HSPN组的血清Cys C水平与血IGF-1、TGF-β1水平比较,存在正相关(r=0.759、r=0.802,均P<0.05),血IGF-1与TGF-β1也存在正相关(r=0.850,P<0.05)。结论:血IGF-1、TGF-β1共同参与紫癜性肾炎发病,其水平变化与病理损害程度相关。
Objective: To investigate the role of insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1) levels in the pathogenesis of renal damage in children with atopicapositis. Methods: Thirty HSP patients, 30 HSPN children and 30 healthy children were selected as the control group. Blood samples were collected and the concentration of IGF-1 in each group was determined by chemiluminescence method. Double-antibody sandwich enzyme-linked immunosorbent assay The concentrations of TGF-β1 in each group were detected. At the same time, the serum Cys C, BUN and SCr levels in all groups were detected by automatic biochemical analyzer. Results: The levels of serum IGF-1 and TGF-β1 in HSPN group, HSP group and control group were significantly different (P <0.05). Serum Cys C levels in control group, HSP group and HSPN group children, the difference was statistically significant (P <0.05). There was a positive correlation between the levels of serum Cys C and IGF-1 and TGF-β1 in HSPN group (r = 0.759, r = 0.802, both P <0.05) There was a positive correlation (r = 0.850, P <0.05). Conclusion: IGF-1 and TGF-β1 participate in the pathogenesis of purpuric nephritis. The level of IGF-1 and TGF-β1 is related to the degree of pathological damage.