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治疗心律失常常采用联合给药,可获良好效果。但联合用药不当,往往发生药物间的相互作用,导致降低疗效,甚至出现毒副反应。本文根据文献资料对几种常用抗心律失常药物与其它药物的相互作用简述如下。一、硫酸奎尼丁1.奎尼丁与狄戈辛合并应用,可使狄戈辛血浓度升高,其机理可能是:奎尼丁抑制肾小管的排泌而降低肾脏的清除,同时减少狄戈辛向组织中分布,并抑制狄戈辛的非肾途径排泄。合并应用,使狄戈辛平均血浓度从1.1nmol/L 增至20nmol/L。有人认为奎尼丁可使狄戈辛从其它组织转移至脑组织,使脑白质内狄戈辛浓度明显增高至50%、出现狄戈辛中毒症状、
Treatment of arrhythmia often used in combination, can be good results. However, inappropriate combination of drugs, drugs often occur between the interaction, resulting in reduced efficacy, and even toxic side effects. This article based on the literature on several commonly used anti-arrhythmic drugs and other drug interactions are summarized as follows. First, quinidine sulfate 1 quinidine combined with Dioxin Xin, Timothy blood concentration can increase its mechanism may be: quinidine inhibition of renal tubular secretion and reduce renal clearance, while reducing Digoxi distributes to tissues and inhibits Digoxin’s non-renal excretion. Combined application, the average blood concentration of Digoxigen from 1.1nmol / L increased to 20nmol / L. Some people think that quinidine can make Digoxin translocation from other organizations to brain tissue, so that the concentration of digoxin in the white matter of the brain was significantly increased to 50%, the symptoms of Digoxin,