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电刺激大脑皮层前外侧回联合(ALA)对隐神经C类纤维传入诱发的体感皮层单位放电(C-CED)有明显的抑制作用,能使C-CED的积分值显著减小,提示大脑皮层联合区可能对C-CED有调制作用;在体感皮层内微电泳γ-氨基丁酸(GABA)能使C-CED明显减小,积分值衰减,呈剂量效应依赖关系,表明GABA能直接抑制体感皮层内对C类纤维传入反应的神经元,提示这些神经元可能有GABA受体存在;微电泳GABA受体阻断剂荷包牡丹碱(BCL)能使ALA对C-CED的抑制作用显著地减弱,进一步提示电刺激ALA可能引起脑内释放GABA,直接作用体感皮层内对C类纤维传入发生反应的神经元,对C-CED产生抑制作用。
Electrical stimulation of anterior cingulate segment (ALA) significantly inhibits somatic cortical discharge (C-CED) induced by saphenous C-fibers and significantly decreases the integral value of C-CED, suggesting that brain Cortical combination zone may modulate C-CED; GABA in somatosensory cortex can significantly reduce C-CED, the integral value decay, showing a dose-dependent relationship, indicating that GABA can directly inhibit The somatic cortical afferent responses to C fibers suggest that these neurons may have the presence of GABA receptors. The inhibitory effect of ALA on C-CED by micro-electrophoresis of GABA receptor antagonist bicuculline (BCL) , Further suggesting that electrical stimulation of ALA may cause the release of GABA in the brain and directly affect the afferent C-CED-induced neurons in the somatosensory cortex.