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目的:观察甲型副伤寒患者血浆P—选择素(P—selectin)水平变化,并探讨其临床意义。方法:应用ELISA分别检测30例甲型副伤寒患者急性期、恢复期及20例健康人血浆中的P—选择素水平。结果:甲型副伤寒患者急性期血浆中的P—选择素水平明显高于健康人对照组(P<0.01),恢复期血浆中的P—素基本恢复正常(P>0.05)。结论:研究表明甲型副伤寒患者血浆P—素水平增高并与病程相关,动态检测血浆P—选择素可作为甲型副伤寒患者病情观察的重要指标。
Objective: To observe the changes of plasma P-selectin in patients with paratyphoid fever and to explore its clinical significance. Methods: The plasma levels of P-selectin in 30 cases of Paratyphus A were detected by ELISA respectively in acute phase, convalescence phase and in 20 healthy subjects. Results: The plasma P-selectin level in patients with acute paratyphoid fever was significantly higher than that in healthy controls (P <0.01). The levels of P-selectin in convalescent patients returned to normal (P> 0.05). Conclusion: The study shows that plasma P-glycoprotein levels are elevated in patients with paratyphoid A and correlated with the course of disease. The dynamic detection of plasma P-selectin can be used as an important indicator of paratyphoid fever.