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目的:探讨伤科熏洗方对佐剂性关节炎(AA)大鼠血清肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)的调节作用。方法:30只Wistar大鼠随机分为对照组、模型组和治疗组,每组10只。模型组和治疗组采用完全弗氏佐剂构建佐剂性关节炎大鼠模型,治疗组采用伤科熏洗方外用熏洗治疗。观察AA大鼠足趾肿胀、关节炎指数、病理改变以及血清TNF-α和IL-1β的变化。结果:与对照组相比,AA大鼠足趾明显肿胀,炎症指数增高,病理改变明显,血清TNF-α和IL-1β水平显著升高;经伤科熏洗方治疗后,足趾肿胀明显消退,炎症指数降低,病理改变减轻,血清TNF-α和IL-1β水平明显下降(P<0.05)。结论:伤科熏洗方可能通过抑制炎症因子TNF-α和IL-1β的表达,达到治疗大鼠佐剂性关节炎的作用。
Objective: To investigate the regulation effect of Zongkexu prescription on serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in adjuvant arthritis (AA) rats. Methods: Thirty Wistar rats were randomly divided into control group, model group and treatment group, with 10 rats in each group. The adjuvant arthritis rat model was established by complete Freund’s adjuvant in the model group and the treatment group. The treatment group was treated by external fumigation with Shangkexu Fang. To observe the swelling of the toes, the arthritis index, pathological changes and the changes of serum TNF-α and IL-1β in AA rats. RESULTS: Compared with the control group, the AA rats had obvious swelling of the toe, increased inflammation index, obvious pathological changes and significant increase of the levels of serum TNF-α and IL-1β. The swelling of the toe was obviously (P <0.05). The levels of TNF-α and IL-1β in serum decreased significantly (P <0.05). CONCLUSION: SCI may be effective in adjuvant arthritis in rats by inhibiting the expression of inflammatory cytokines TNF-α and IL-1β.