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目的:探讨40岁以下急性心肌梗死(AMI)患者血尿酸、血脂及冠状动脉病变特点。方法:回顾分析2007年12月～2010年12月就诊于北京友谊医院,并确诊为AMI的40岁及以下患者(青年组)42例,与40岁以上的AMI患者380例(中老年组)进行对照研究,分析其血尿酸、血脂等危险因素以及冠脉病变程度的不同特点。结果:青年组患者血尿酸水平、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、体质量指数(BMI)、男性及吸烟者比例显著高于中老年患者,具有统计学差异;冠脉造影显示青年组单支血管病变明显多于老年组,而双支与多支病变则显著少于中老年组。通过多元相关分析,AMI患者血尿酸与性别、BMI、TG、糖化血红蛋白(HbA1c)相关,与年龄无明显相关。消除BMI、TG、HbA1c影响,两组患者血尿酸仍有统计学差异。结论:与中老年组比较,青年组AMI患者血尿酸水平、脂代谢异常及BMI明显升高,冠脉病变以单支血管病变较常见;男性患者为主。
Objective: To investigate the changes of serum uric acid, lipids and coronary lesions in patients under 40 years of age with acute myocardial infarction (AMI). Methods: Forty-two patients aged 40 years and under (young group) were enrolled in Beijing Friendship Hospital from December 2007 to December 2010 and were diagnosed as AMI. A total of 42 patients with AMI over 40 years old (middle-aged and elderly group) Control study, analysis of its blood uric acid, blood lipids and other risk factors as well as the different characteristics of coronary artery disease. Results: The serum uric acid level, LDL-C, triglyceride (TG), body mass index (BMI), male and smoker in youth group were significantly higher than those in middle-aged and elderly patients, with statistical difference Coronary angiography showed that the single vessel disease in young group was significantly more than that in the elderly group, while the double-vessel and multi-vessel disease were significantly less than those in the middle-aged group. By multivariate correlation analysis, serum uric acid in patients with AMI was correlated with gender, BMI, TG, HbA1c, but not with age. Elimination of BMI, TG, HbA1c the impact of serum uric acid between the two groups were still statistically significant. Conclusion: Compared with middle-aged and elderly patients, serum uric acid level, abnormal lipid metabolism and BMI were significantly increased in young patients with AMI. The coronary artery lesion was more common in single vessel disease, while male patients were predominant.