Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs

来源 :中国病毒学 | 被引量 : 0次 | 上传用户:doujiazhi
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Dear Editor,Marburg virus (MARV) belongs to the Filoviridae family,along with the related Ebola virus (EBOV).Although MARV is less renowned than EBOV,it causes an equally devastating disease,with clinical symptoms similar to EBOV infection and a remarkably high mortality rate.To date,about 600 MARV cases have been reported globally,with an average mortality rate of around 80% (Brauburger et al.2012).Due to the severity of disease caused by MARV,as well as its threat to global public health,MARV is classified as a risk group 4 pathogen by WHO,neces-sitating containment measures equivalent to biosafety level 4 (BSL-4).Moreover,MARV is considered a potential agent of bioterrorism (Leffel and Reed 2004) and,since 2015,has been listed as one of ten priority pathogens on WHO\'s Blueprint of Priority.However,drug development specific for MARV is seldomly reported,although some studies for drugs against EBOV have identified compounds that may also be effective against MARV (Madrid et al.2013;Bixler et al.2017;Cross et al.2018).MARV is a single-stranded negative-sense RNA virus.
其他文献
期刊
@@
Previous studies indicated that fruit bats carry two betacoronaviruses,BatCoV HKU9 and BatCoV GCCDC1.To investigate the epidemiology and genetic diversity of these coronaviruses,we conducted a longitudinal surveillance in fruit bats in Yunnan province,Chi
Dear Editor,rnTick-borne encephalitis virus (TBEV) belongs to the genus Flavivirus within the family Flaviviridae and includes three subtypes:Siberian,European,and Far Eastern.TBEV infects humans via tick bites;indeed,at least 10,000 human cases of enceph
期刊
期刊
@@
The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency.SARS-coronavirus-2 (SARS-CoV-2),the causative pathogen of COVID-19,is a positive-sense single-stranded RNA virus belonging to the family Coronaviridae.
Mycoviruses have been found to infect more than 12 species of Penicillium,but have not been isolated from Penicillium italicum (P.italicum).In this study,we isolated and characterized a new double-stranded RNA (dsRNA) virus,designated Penicillium italicum
Hand,foot and mouth disease (HFMD) is a major public health concern in China.The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16).Since its first large outbreak in
The mechanism of how SARS-CoV-2 causes severe multi-organ failure is largely unknown.Acute kidney injury (AKI) is one of the frequent organ damage in severe COVID-19 patients.Previous studies have shown that human renal tubule cells could be the potential
Vectored vaccines based on highly attenuated modified vaccinia Ankara (MVA) are reported to be immunogenic,tolerant to pre-existing immunity,and able to accommodate and stably maintain very large transgenes.MVA is usually produced on primary chicken embry
Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%.Vaccination is the most effective way to prevent rabies in humans and animals.In this study,the rel