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目的：研究靛玉红肟甲醚的合成及构效关系。方法：用靛玉红、NH2OH·HCL、CH3I在乙醇中直接合成靛玉红肟甲酸并得到其晶体；用FT-IR170SX光谱法、JEDL－JNM－FX90Q，HNMR光谱法、CarloErba1106元素分析法、CAD4衍射法是靛玉红肟甲醚分子结构和晶体结构；用美兰试验测抗白血病活性。结果：测定出靛玉红肟甲醚的分子结构和晶体结构，并得出靛玉红肟甲醚的抗白血病活性优于靛玉红。结论：肟甲醚结构＞C＝N－OCH3对靛玉红类药物抗白血病活性有重要作用，对寻找这类新药有重要意义。
Objective: To study the synthesis and structure-activity relationship of indirubin. Methods: The indirubin oxime formic acid was synthesized directly from indomethacin, NH2OH · HCL and CH3I in ethanol and its crystal was obtained. The structure of the indirubin was determined by FT-IR170SX spectrometry, JEDL-JNM-FX90Q, HNMR spectroscopy, CarloErba1106 elemental analysis, Diffraction method is indirubin oxime methyl ether molecular structure and crystal structure; with melanin test anti-leukemia activity. Results: The molecular structure and crystal structure of indirubin were determined. The antileukemic activity of indirubin was superior to that of indirubin. CONCLUSION: The structure of oxime-methyl ether> C = N-OCH3 plays an important role in the anti-leukemia activity of indirubin and is of great significance for finding new drugs of this kind.