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本实验用雄性Wistar大白鼠建立局灶性脑梗塞动物模型。用离子选择性微电极动态检测大鼠正常脑皮层及大脑中动脉凝闭后脑梗塞区细胞外Na~+、K~+、Ca~(++)浓度变化。结果显示:大脑中动脉凝闭后1～2分钟脑梗塞区细胞外Na~+浓度迅速从正常平均浓度138.45±10.64mM(X±SD)降至127.5±10.98mM,K~+浓度从4.72±0.38mM升到6.00±1.10mM,Ca~(++)浓度从1.23±0.05mM降到1.19±0.06mM,并随着脑梗塞时间延长Ca~(++)浓度逐渐下降。
In this experiment, animal models of focal cerebral infarction were established in male Wistar rats. The changes of extracellular Na ~ +, K ~ + and Ca ~ (++) concentrations in cerebral infarction area after normal cerebral cortex and middle cerebral artery occlusion in rats were detected by ion selective microelectrode. The results showed that the concentration of extracellular Na ~ + in cerebral infarction area decreased rapidly from the normal average concentration of 138.45 ± 10.64mM (X ± SD) to 127.5 ± 10.98mM and the concentration of K + increased from 4.72 ± 0.38mM to 6.00 ± 1.10mM. The concentration of Ca ~ (++) decreased from 1.23 ± 0.05mM to 1.19 ± 0.06mM, and the concentration of Ca ~ (++) decreased gradually with the prolongation of cerebral infarction.