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应用流式细胞仪检测39例大肠癌患者手术前后T细胞表面6种细胞表型,发现随着Dukes分期的增高,术前CD3、CD4、CD4/CD8、CD16、CD69及CD3+/HLA-DR+逐渐下降,CD8逐渐增高(P<0.05);A期大肠癌患者机体免疫功能活跃,术前CD3、CD4高于对照组(P<0.05),CD8、CD4/CD8、CD16、CD3+/HLA-DR+与对照组相同;根治及姑息性切除术后,CD8降低,CD3、CD4、CD4/CD8、CD16、CD69、CD3+/HLA-DR+升高(P<0.05);肿瘤未切组术后CD3、CD16、CD4/CD8进一步下降(P<0.05)。提示大肠癌患者术前免疫状态与疾病的程度呈负相关,切除肿瘤有益于改善患者细胞免疫功能。
Flow cytometry was used to detect the phenotypes of 6 kinds of cells on the surface of T cells before and after operation in 39 patients with colorectal cancer. It was found that the preoperative CD3, CD4, CD4 / CD8, CD16, CD69 and CD3 + / HLA-DR + CD8, CD4 / CD8, CD16 and CD3 + / CD8 were higher in the patients with stage A colorectal cancer than those in the control group (P <0.05) The levels of CD8, CD4, CD4 / CD8, CD16, CD69, CD3 + / HLA-DR + were significantly increased in the control group after the radical and palliative resection (P <0.05) Postoperative CD3, CD16, CD4 / CD8 decreased further (P <0.05). Prompted that the preoperative immune status of patients with colorectal cancer and the degree of disease was negatively correlated, resection of the tumor is beneficial to improve cellular immune function.