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本文测定了健康儿童血和尿β_2微球蛋白(β_2m)正常值,观察了几种儿科常见肾脏病血和尿β_2m变化。在急性肾炎早期血β_2m可有轻度增高。肾病综合征和IgA肾病有少数病例血和/或尿β_2m增高。狼疮肾炎和过敏性紫癜肾炎部分病例血β_2m增高,而尿β_2m增高更显著。尿毒症病例血β_2m与血肌酐(SCr)、血尿素氮(BUN)呈正相关,与肌酐清除率(Ccr)呈负相关。尿β_2m测定肾小管功能较酚红排泄试验和莫氏试验敏感,并能反映出肾小管病理改变。
This article measured the normal blood and urine β_2 microglobulin (β_2m) normal values observed several pediatric common kidney disease blood and urine β_2m changes. In the early stage of acute nephritis blood β_2m may be slightly increased. Nephrotic syndrome and IgA nephropathy in a few cases of blood and / or urine β_2m increased. In some cases of lupus nephritis and allergic purpura nephritis blood β_2m increased, while urine β_2m increased more significantly. Β_2m in uremia cases was positively correlated with serum creatinine (SCr) and blood urea nitrogen (BUN), but negatively correlated with creatinine clearance (Ccr). Urine β_2m determination of renal tubular function than phenol red excretion test and Moxibustion test sensitive and can reflect the pathological changes of renal tubules.