类风湿关节炎 (rheumatoidarthritis ,RA)是一种慢性进展性疾病 ,约半数患者发病 2a内就可出现不可逆的关节破坏 ,导致畸形 ,如果在疾病的早期接受治疗 ,能有效阻止病情发展。但至今 ,其诊断主要依据 1987年美国风湿病学会制订的分类诊断标准 ,其中类风湿因子 (RF)为惟一的血清 Rheumatoid arthritis (RA) is a chronic, progressive disease in which about half of the patients develop irreversible joint destruction within 2 years of onset, resulting in deformities that can be effectively prevented if they are treated early in the disease. However, up to now, the diagnosis is mainly based on the classification diagnostic criteria formulated by the American College of Rheumatology in 1987, in which rheumatoid factor (RF) is the only serum