论文部分内容阅读
目的了解江苏省健康人群脊髓灰质炎中和抗体水平,为及时制定免疫策略、维持无脊灰状态提供科学依据。方法采取江苏省2009年-2013年健康人群血清标本,应用细胞中和实验法检测脊灰中和抗体。SPSS 18.0统计软件进行统计分析。结果共检测3 000名健康人群的血清标本,脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为98.51%、98.37%、94.97%;几何平均滴度(GMT)分别为1∶186.21、1∶125.89、1∶47.86;不同年份健康人群脊灰抗体阳性率和GMT无统计学意义(P>0.05);不同年龄段健康人群脊灰抗体阳性率及GMT有统计学意义(P<0.05),抗体水平总趋势随年龄增长递减。结论江苏省健康人群脊灰抗体阳性率和几何平均滴度,近5年均保持在较高水平,接种脊灰疫苗可获得较好的免疫保护。今后应继续保持高水平的免疫覆盖率,进一步改进免疫策略及提高AFP病例监测系统的敏感性,巩固无脊灰成果。
Objective To understand the level of poliomyelitis neutralizing antibodies in healthy population in Jiangsu Province and provide a scientific basis for timely development of immunization strategies and maintenance of polio-free status. Methods Serum samples of healthy people from 2009 to 2013 in Jiangsu Province were collected. Neutralization antibody was detected by cell neutralization assay. SPSS 18.0 statistical software for statistical analysis. Results Serum samples of 3 000 healthy people were detected. The positive rates of type I, II and III antibodies were 98.51%, 98.37% and 94.97% respectively. The geometric mean titers (GMTs) were 1: 186.21 and 1: 125.89 , 1:47.86 respectively; The positive rates of poliovirus and GMT in healthy population in different years were not statistically significant (P> 0.05); the positive rate of poliovirus and GMT in healthy population at different ages were statistically significant (P <0.05) The general trend diminishes with age. Conclusions The positive rate and geometric mean titer of poliovirus in healthy population in Jiangsu Province have been kept at a high level for nearly 5 years. The poliovirus vaccine can be used for better immune protection. In the future, we should continue to maintain a high level of immunization coverage, further improve our immunization strategy and enhance the sensitivity of the AFP case surveillance system, so as to consolidate the results of no polio.