DEAR EDITOR:Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer,cardiovascular disease,dementia,and stroke(Andersen et al,2012).Though there may be a number of underlying mechanisms behind this longevity,curiously it seems that the survival advantage persists in their offspring(Terry et al,2003),suggesting a potentially important role for genetic factors.Previous studies suggested that the heritability of human longevity may be~25%(Herskind et al,1996;Mcgue et al,1993),whicih is consistent with other studies on model DEAR EDITOR: Centenarians are a typical longevity model characterized by delayed onset of morbidity in age-related diseases such as cancer, cardiovascular disease, dementia, and stroke (Andersen et al, 2012) .Though there may be a number of underlying mechanisms behind this this longevity, curiously it seems that the survival advantage persists in their offspring (Terry et al, 2003), suggesting a potentially important role for genetic factors. Previous studies suggest that the heritability of human longevity may be ~ 25% (Herskind et al, 1996 ; Mcgue et al, 1993), whicih is consistent with other studies on model