论文部分内容阅读
基础和临床研究已证实,抑郁症的发生与前额皮质和海马等脑区的神经可塑性功能异常有关,脑源性神经营养因子及其所介导的信号通路在神经可塑性调节以及抑郁症的发生中起重要作用。氯胺酮或东莨菪碱抗抑郁作用快速起效,长时程维持;它们通过快速激活脑源性神经营养因子相关信号通路,调节神经元可塑性,从而逆转抑郁样症状。本文就快速起效抗抑郁药的神经可塑性机制研究进行系统的综述,为今后新型抗抑郁药研发提供理论依据。
Basic and clinical studies have confirmed that the occurrence of depression and prefrontal cortex and hippocampus and other neuroplasticity dysfunction, brain-derived neurotrophic factor and its signal transduction pathway in the regulation of neuroplasticity and the occurrence of depression makes an important impact. Ketamine or scopolamine have rapid onset of antidepressant action and long-term maintenance; they reverse the depressive symptoms by rapidly activating brain-derived neurotrophic factor-related signaling pathways and modulating neuronal plasticity. This article reviews the mechanism of neural plasticity of antidepressant in rapid onset and provides a theoretical basis for the future development of new antidepressants.