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目的：研究Ⅳ型胶原与子宫颈癌浸润及转移的关系。方法：采用免疫组化方法对65例宫颈浸润癌进行Ⅳ型胶原的表达。结果：Ⅱb-Ⅲa期子宫颈癌基底膜断裂或缺损明显多于Ⅰ-Ⅱa期（P＜0．025）。早期子宫颈浸润爆发生淋巴结转移组其基底膜断裂或缺损程度明显高于未转移组，（P＜0．005）。结论：子宫颈癌浸润破坏基底膜程度与临床分期有关，Ⅳ型胶原表达越差分期越高。早期宫颈浸润癌Ⅳ型胶原表达差者易发生淋巴结转移，由此可做为判断子宫颈癌浸润转移的生物学指标之一。
Objective: To study the relationship between type Ⅳ collagen and the invasion and metastasis of cervical cancer. Methods: The expression of type Ⅳ collagen in 65 cases of invasive cervical carcinoma was detected by immunohistochemistry. Results: Basement membrane rupture or defect in stage Ⅱb-Ⅲa cervical cancer was more than that in stage Ⅰ-Ⅱa (P <0.025). The rate of rupture or defect of basement membrane in early invasive cervical lymph node metastasis was significantly higher than that in non-metastatic group (P <0.005). Conclusion: The degree of invasion and destruction of the basement membrane of cervical cancer is related to the clinical stage. The worse the expression of type Ⅳ collagen is, the higher the staging is. Early cervical invasive carcinoma of type IV collagen expression is prone to lymph node metastasis, which can be used as a biological indicator to determine the invasion and metastasis of cervical cancer.