目的：探讨钛网包裹打压植骨修复大段骨缺损的初步治疗效果。方法2009年1月~2012年12月,采用钛网包裹打压植骨修复6例长骨骨折后大段骨缺损。骨折骨缺损部位：股骨和肱骨各1例，胫骨、桡骨各2例。骨缺损长度5.2～9.0 cm，平均6.5 cm。固定方法：髓内钉2例，钢板4例。合并肌腱神经损伤2例。在双侧髂后部或和髂前部等处切取骨缺损体积2倍以上大量松质骨，用钛网包裹骨缺损处两端，将颗粒状骨打压植于钛网内。骨缺损恢复长度5.2～9.0 cm，平均6.3cm。结果切口均I期愈合。术后随访12～46个月，平均18个月，骨缺损处均骨性愈合，临床愈合时间4.0～6.5个月，平均5.1个月，无固定物松动断裂；至末次随访，临近关节活动度：优1例、良4例、可1例。结论钛网包裹打压植骨修复大段骨缺损，具有简便、安全、临床愈合较快、效果良好等优点。“,”Objective To investigate the preliminary outcomes of wrapped impacted bone graft using titanium mesh for repair of large segmental bone defect. Methods From January 2009 to December 2012,6 cases of large segmental bone defect of lone bone after fractures were treated with wrapped impacted bone graft using titanium mesh to repair the defect. The location of fracture and defect:1 respective casein femur and humerus,2 respective cases in tibia and radius.The length of bone defect was from 5.2 cm to 9.0 cm with an average of 6.5cm.Fixation methods:intramedullary nail was used in 2 cases and plate in 4 cases.collateral injuries such as tendon or nerve injury could be foundin 2 cases. Cancellous bone with a volume two times than the defect bone was harvested from theposterior or/and anterior segments of the bilateral ilium etc. Titanium mesh was used and placed to wrap the defect, then the bone granules was impacted closely into the titanium mesh.The recovered length of bone defect was from 5.2 cm to 9.0 cm with an average of 6.3 cm. Results Incisions underwent primary healing. Following-up ranging from 12 to 46 months, with an average of 18 months,revealed that all fractures with bone defects healed; the clinical healing time ranged from 4.0 months to 6.5 months with an average of 5.1 months. no breakingor loosening of the fixator was noted.at the last follow-up,the function of the adjacent joints was excellent in 1 case, good in 4 cases and fair in 1 case. Conclusion Wrapped impacted bone graft using titanium mesh for repair of large segmental bone defect has advantages of bing simple, safe, fast in healing and excellent in efficacy.